Correlation of Before and After Invasive Breast Cancer Neoadjuvant Chemotherapy for NFkB, Cyclin D1, and Survivin Expression

Background & Objective: Patients undergoing neoadjuvant chemotherapy (NC) for invasive breast cancer (IBC) therapy need biomarkers to track their progress. Because of the relationship between NFkB, Survivin, and Cyclin D1 with NC resistance, different expression levels each these can be pre- post-NC in IBC. However, no research has examined correlation before after expression. This study aimed determine among them.Methods: Biomarkers (low high) was used classify 30 samples. ER, PR, HER2, Ki-67 status, tumor grade, age, response were assessed. The amounts D1, NFkB evaluated using immunohistochemistry, samples classified based on cut-off. Chi-square linear regression evaluate data.Results: No significant association found changes both NC. Significant moderate correlations shown Survivin (r = 0.513) 0.543). not significant.Conclusion: high potential proteins as prognostic indicators demonstrated by strong positive upregulation indicates chemoresistance developing IBC presence